Novák, Aleš, 1999-
Biofyzikální charakterizace chování karbosilanových amfifilních dendronů ve vodném roztoku [rukopis] / Aleš Novák. -- 2023. -- 79 l. (118 157 znaků) : il., grafy, tab. -- Oponent Jan Malý. -- Ved. práce Dominika Wróbel. -- Abstrakt: Amphiphilic dendrons, highly branched polymers with hydrophobic and hydrophilic parts which possess a highly accurate chemical structure, have been reported in many articles and publications to be very promising in medical treatment and other biomedical or bioanalytical applications. This work aims to introduce new types of amphiphilic carbosilane dendrons and characterize their behavior in a water solution with several biophysical methods to obtain data about specific properties such as size, dispersity, or stability. The importance of studying the behavior of these molecules in a water solution corresponds with the fact that amphiphilic molecules form in an aqueous environment complex, self-assembled structures. Fundamental principles of self-assembling processes, dendrons' properties, and synthetic pathways are mentioned in the theoretical part of the thesis. Current applications of dendrons are also mentioned. Characterization was carried out using Dynamic light scattering measurement, Zeta potential measurement, Isothermal Titration Calorimetry measurement, Transmission Electron Microscopy imaging, and Fluorescence Microscopy imaging.. -- Abstrakt: Amphiphilic dendrons, highly branched polymers with hydrophobic and hydrophilic parts which possess a highly accurate chemical structure, have been reported in many articles and publications to be very promising in medical treatment and other biomedical or bioanalytical applications. This work aims to introduce new types of amphiphilic carbosilane dendrons and characterize their behavior in a water solution with several biophysical methods to obtain data about specific properties such as size, dispersity, or stability. The importance of studying the behavior of these molecules in a water solution corresponds with the fact that amphiphilic molecules form in an aqueous environment complex, self-assembled structures. Fundamental principles of self-assembling processes, dendrons' properties, and synthetic pathways are mentioned in the theoretical part of the thesis. Current applications of dendrons are also mentioned. Characterization was carried out using Dynamic light scattering measurement, Zeta potential measurement, Isothermal Titration Calorimetry measurement, Transmission Electron Microscopy imaging, and Fluorescence Microscopy imaging.
Malý, Jan, 1974-. Wróbel, Dominika. Univerzita J.E. Purkyně v Ústí nad Labem. Centrum nanomateriálů a biotechnologií
Carbosilane dendrons. amphiphilic molecules. self-assembly. drug delivery. nanomedicine. DLS. Zeta potential. ITC. TEM. Carbosilane dendrons. amphiphilic molecules. self-assembly. drug delivery. nanomedicine. DLS. Zeta potential. ITC. TEM. bakalářské práce
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